1.College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 2.School of Life Science, Xiamen University, Xiamen 361005, China; 3.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Abstract:Nuclear hormone receptors (NRs) belong to a large protein superfamily that are important transcriptional modulator in metazoan and play vital role in metabolism including cell differentiation and proliferation. NRs share a common tertiary structure, the typical NR contains an N-terminal A/B domain, a highly conserved DNA binding domain (DBD), a hinge (D domain), and a C-terminal ligand binding domain (LBD). The nuclear receptors in parasitic platyhelminths were reported so far only in the Schistosoma mansoni and Schistosoma japonicum. The aim of this review is to examine the current knowledge of nuclear receptors in parasitic platyhelminths that provide the reference for further research.
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