Abstract:Zika virus (ZIKV), an important mosquito-transmitted flavivirus, causes epidemics affecting millions of people on multiple continents and leads a public health concern. Zika outbreak caused global attention for its severely differed historical clinical consequences as neonatal microcephaly, abnormal brain development and Guillain-Barre syndrome particularly in Central and South America since 2015. Appropriate animal infection model is of great significance for studying the ZIKV transmission mechanism, pathogenesis and development of therapy drugs, vaccines and diagnostic reagents for preventing Zika infection. Here, we review the recent advances of several animal infection models for Zika virus that have been established in recent years.
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