Etiological characterization of indigenous dengue cases in Fujian province, 2015
ZHANG Yong-jun, WU Sheng-gen, WANG Jin-zhang, YOU Li-bin, KAN Nai-peng, WENG Yu-wei
1.Fujian Center for Disease Control and Prevention, Fuzhou 350001, China; 2. Fujian Provincial Key Laboratory of Zoonosis Disease Research, Fuzhou 350001, China
Abstract：Introduction of dengue viruses from dengue-endemic regions may lead to indigenous outbreaks in regions with high density of mosquito vectors. During mid-September to mid-October in 2015, a total of 41 indigenous dengue cases emerged in 4 clusters were notified in Fujian province, China. In this study, the etiological characterization of clinical isolates linked to these outbreaks was investigated. It was revealed by phylogenetic analyses on the full-length coding sequences that the 9 dengue serotype 1(DENV1) isolates, belonging to genotype 1(G1), showed high similarity in nucleotide sequences, and that the 8 dengue serotype 2 (DENV2) isolates showed distinct variations within the genotype of Cosmopolitan. According to the phylogenetic trees, DENV1 strains associated with clusters 2 and 4 were likely originated from Sri Lanka, while Malaysia and India were sources of the DENV2 strains associated with Cluster 1 and Cluster 3, respectively. Therefore, these results suggested that multiple sources of introduction caused the indigenous dengue outbreaks in Fujian province, 2015.
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2019, Vol. 35 
