Epidemiological and genetic evolutionary characteristics of avian influenza A (H7N9) Virus in Shaanxi Province from 2017 to 2018
SHI Wei1,2, LI Shen1, WU Rui3, ZHANG Jun-jun4, LI Jun5, GAO Tao6, JIAO Ya-dong7, ZHANG Lei1, XU Yi1,2, ZHANG Shao-bai1, YU Peng-bo1
1.Shaanxi Provincial Centre for Disease Control and Prevention, Xi’an 710054, China; 2.Medical College of Xi’an Jiaotong University, Xi’an 710061, China; 3.Xi’an Centers for Disease Control and Prevention, Xi’an 710054, China; 4.Xianyang Centers for Disease Control and Prevention, Xianyang 712000, China; 5.Tongchuan Centers for Disease Control and Prevention, Tongchuan 723031, China; 6.Baoji Centers for Disease Control and Prevention, Baoji 721006, China; 7.Yulin Centers for Disease Control and Prevention, Yulin 719000, China
Abstract：To investigate the epidemiological characteristics and genome sequences of human infections with avian influenza A(H7N9)virus in Shaanxi Province from 2017 to 2018. This study can provide the scientific basis for the effective prevention and control of human infected H7N9 avian flu. The specimens of surrounding environment and H7N9 patients were collected for influenza virus detection. The avian influenza virus isolation and genome sequence analysis were from Chinese National Influenza Center. From May 2017 to March 2018, the positive rate of the H7N9 virus in 142 environment specimens was only 4.91‰, 7 cases and 2 avian epidemic situations were found. The HA protein cleavage site had a “KRTA” insertion, which is a molecular characterization of a highly pathogenic strain. As results, the viral HA and NA sequences in Shaanxi Province were highly homologous to viral sequences in the Yangtze River Delta. In conclusion, the epidemic strains of Shaanxi virus had the characteristics of genetic diversity, and there are 2 varieties, low pathogenicity and high pathogenicity. In the future, the monitoring of pathogens and genetic variation analysis continued to provide a scientific basis for defending and monitoring the epidemic of Avian Influenza Virus.
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2020, Vol. 36 
