Abstract:A retrospective study was used to analyze the situation of antibody against COVID-19. The serum samples of confirmed cases of COVID-19, non-case of COVID-19 and the population serum collected before 2019 were tested in laboratory. Epidemiological information and laboratorial test results are used in combination for analysis. We found that the sensitivity of 2019-nCoV antibody detection reagent (immunochromatography) was 71.43%; the specificity was 98.41%; the diagnostic accuracy was 91.67%; the positive predictive value was 93.75% and the negative predictive value was 91.18%. Antibody detection with immunochromatography is a good complement to the clinical diagnosis and nucleic acid detection diagnosis about COVID-19. Since the sensitivity needs to be improved, it should be used in combination with other methods. The serum specimens within 1-18 days after the onset were collected. The positive detection rate of specimens collected prematurely is low, and the amount of detoxification in the throat does not affect the positive rate of antibody detection.In order to improve the detection rate of antibodies, we should collect serum samples more than 6 days after the onset to test.
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