Prevalence of latent tuberculosis infection and its related risk factors in rural Xiangtan County
YIN Shi-lin1, XU Zu-hui2, XU Hui-lan1, TAN Yun-hong2, CHEN Tian-zhu3, ZHANG Hao-ran4, LIU Li-qin2, HUANG Guo-jun2, BAI Li-qiong2, GAO Lei4
1. Department of Social Medicine and Health Management,Xiangya School of Public Health of Central South University,Changsha 410078, China; 2. Hunan Provincial Chest Hospital,Tuberculosis Control Institute of Hunan Province, Changsha 410013,China; 3. Xiangtan County Center for Diseases Control and Prevention, Xiangtan 411228, China; 4. Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
Abstract:To explore the prevalence of latent tuberculosis infection (LTBI) and its risk factors for rural residents of Xiangtan county. The cross-sectional study was conducted in six villages which selected by random cluster sampling method in Zhonglupu town, Xiangtan County. The residents who were born before June 1, 2008 (≥5 years old) were recruited in the study. Interferon gamma release assay (IGRA) was used to detect tuberculosis (TB) infection. Using univariate analysis and multiple logistic regression methods, the related risk factors were identified. 4913 actually participated from 5440 eligible participants, with a response rate of 90.3%. Overall, 26.0% (1 276/4 913) of participants were Quanti-FERONTB Gold In-Tube (QFT) positive. Higher positive QFT results in men (29.8%, 660/2 216) were observed than that in women (22.8%, 616/2 697) (χ2=30.502, P<0.001). An increasing trend for QFT positivity with increasing age was also noted (P for trend <0.001). Factors significantly associated with QFT positivity were identified as history of smoking(OR=1.684,95%CI=1.462~1.939), 46~60 years:OR=2.076, 95%CI=(1.748~2.465); >60 years:(OR=3.152,95%CI=2.655~3.741), BMI<18.5 kg/m2:(OR=1.792,95%CI=1.397~2.300), BMI between 24 to 27.9 kg/m2 (OR=2.037,95%CI=1.563~2.656), BMI≥28kg/m2(OR=2.597,95%CI=1.899~3.551), history of close contact with a TB patient(OR=1.214,95%CI=1.021~1.442. In conclusion, the prevalence of latent tuberculosis infection in rural residents of Xiangtan county was relatively high and the elderly people, smokers, people with abnormal BMI, and people with close contacts with patients of tuberculosis might be potential target populations, who should be taken some key measures, such as monitoring of latent tuberculosis infection.
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