Abstract：Tuberculosis is a serious threat to human health, and its prevention and control are critical. Research on detecting tuberculosis risk can aid in its prevention. Tuberculosis infections are highly prevalent in China, and most patients have latent tuberculosis infections (LTBI), which are the source of endogenous disease. Approximately 5%-10% of people with LTBI develop tuberculosis in their lifetime. Tuberculosis risk prediction and drug intervention aid in preventing the development of LTBI into active tuberculosis and play an important role in tuberculosis control. Currently, no gold standard exists for LTBI diagnosis, nor is there an authority publishing biological warning indicators for predicting the risk of progression of LTBI to active tuberculosis. This article reviews the research progress on the development of active tuberculosis from LTBI according to three aspects: transcriptomics, proteomics, and immunomics. In addition, potential research directions for tuberculosis risk detection are described.
周崇兴, 林定文. 基于组学检测的结核病发病风险研究进展[J]. 中国人兽共患病学报, 2020, 36(11): 934-939.
ZHOU Chong-xing, LIN Ding-wen. Research progress on determining tuberculosis risk through on omics detection. Chinese Journal of Zoonoses, 2020, 36(11): 934-939.
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2020, Vol. 36 
