Abstract:The effect of Cyclosporin A on the immune functions of mice infected with Trichinella spiralis was investigated in the present study, in which mice were infected with T.spralis, and Cyclosporin A (CsA) was given intraperitoneally 11 days after infection. At different periods, the content of IL-2 in peripheral blood was determined by ELISA,and the percentages of CD~+_4 and CD~+_8 cells in peripheral blood were tested by using flow cytometry. It was demonstrated that the content of IL-2 in peripheral blood of mice 1-5 weeks after infection was significantly increased than in the normal mice, but it decreased significantly in CsA treated group of mice one week after infection, and there was no difference between the infection group and the CsA-treated group of mice during 2-4 weeks.Meanwhile, the percentage of CD~+_4 cells in the infection group was significantly decreased in comparison with that of normal mice group and that of CD~+_8 cells was significantly increased, thus leading to a definite lowering of the CD_4/CD_8 ratio. It suggests that Cyclosporin A shows immunoregulatory effect on the T.spiralis infection in mice.
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