Abstract:To detect levels of interleukin-18(IL-18) in patients with epidemic encephalitis B in children and to evaluate its clinical signiftcace, the levels of IL-18 in serum and cerebrospinal fluid were measured in 33 patients with epidemic encephalitis B by a double-antibody sandwich ELISA. It was found that the level of IL-18 was significantly higher in fastigium of epidemic encephalitis B than that of controls group (P<0.01). The average value of severe type in patients with epidemic encephalitis B was significantly higher than that of the common type (P<0.01), and level of IL-18 was still higher than that of controls group in convalescence(P<0.01). There were no significant difference between the common type group and controls patients at convalescence. These findings indicates that IL-18 may participate in the antiviral process of encephalitis B, but the high concentrations of IL-18 have also related with the degree of parenchymal lesions of brain. The elevation of IL-18 may be an important marker of the parenchymal lesions of brain in patients with epidemic encephalitis B, and have some reference value in the immunoloregulation of treatment for epidemic encephalitis B.
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