Abstract：To investigate the effect of anti-parasite drugs,different concentrations of praziquantel(PQZ),abendazole(ABZ),fenbendazole(FBZ) and mebendazole(MBZ) were added into the standard reaction system catalized by lactate dehydrogenase from Clonorchis sinensis(CsLDH) and the ABSorbance of NADH at 340 nm wave length was detected.Data were analyzed by using SPSS16.0 software.Compared with the controls,the inhibition rate of 0.2 mmol/L PQZ on CsLDH-catalyzing oxidation-reduction reaction was 94%(P<0.01),while those on CsLDH catalyzing oxidation reaction of 0.2 mmol/L ABZ,0.6 mmol/L FBZ and 0.1 mmol/L MBZ were 84%,92% and 98% respectively(P<0.01)and those on CsLDN reduction reaction were 79%,86% and 87% respectively(P<0.01),From these observations,it suggests that CsLDH may be the target of drug-effect against C.senensis.
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