Abstract:We analyzed the causes of the failure of immunity after the failure of immunization in the case of rabies exposure and provided evidences for control and prevention of rabies among human beings. Data from 70 questionnaires for human rabies cases reported during 2005-2016 in Anhui Province were entered into Epidata3.1 to build a data-base. SPSS 22.0 was used for statistical analysis. Among these cases, 65.71% received treatment from medical institutions in 24 hours after exposure. 81.43% did not get full-access vaccination, and the main reason was that they had fluke mind and were unwilling to complete the vaccination. The usage rate of antiserum immunoglobulin was only 2.86%. The 48.57% did not get treatment in rabies post-exposure outpatient. The median of rabies incubation period was 40 d (the shortest period was 9 days, the longest was 10.5 years). It was statistically significant of the difference between exposure position and rabies incubation (χ2=25.01, P<0.01). The key to prevent human rabies and post exposure immunization failure were establishing rabies post exposure compensation mechanism, regulating the circulation of rabies vaccine to combat illegal and counterfeit products strengthening exposure to rabies after disposal of outpatient medical staff skills training and increasing public knowledge, attitude and practice.
曹明华, 宋丹丹. 安徽省70例狂犬病暴露后免疫失败流行病学分析[J]. 中国人兽共患病学报, 2018, 34(4): 382-384.
CAO Ming-hua, SONG Dan-dan. Epidemiological analysis of immune failure in 70 cases of rabies in Anhui Province, China. Chinese Journal of Zoonoses, 2018, 34(4): 382-384.