Abstract：Helicobacter hepaticus (H.h) is a zoonosis pathogen, its infection is closely related to its multi-system diseases. Hh-induced-diseases are associated with virulence factors. Among these factors, cytolethal distending toxin (CDT) has been mostly elucidated. It could not only arrest cell growth in G2/M phase of eukaryotic cell cycle, causing apoptosis, but also activate the nuclear factor-kappa B pathway, releasing cytokines, and initiate inflammatory response. The flagellin and the adhesion, DNA binding protein from starved cells (DPS), antioxidase and urease are helpful for H.h to colonize, grow and play pathogenic roles in intestinal tract. Virulence genes include a type Ⅵ secretion system (T6SS), it can release virulence proteins into the host, initiating immune response. In this review, the virulence factors of H.h and their pathogenic roles are described for further understanding of the potential pathogenic mechanism of H.h.
曹舒扬,于宁,冯洁,钱淼,孙靖谕,谢灵志,张泉. 肝螺杆菌致病机制的研究进展[J]. 中国人兽共患病学报, 2018, 34(6): 574-578.
CAO Shu-yang, YU Ning, FENG Jie, QIAN Miao, SUN Jing-yu, XIE Ling-zhi, ZHANG Quan. Research progress on the pathogenesis of Helicobacter hepaticus. Chinese Journal of Zoonoses, 2018, 34(6): 574-578.
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2018, Vol. 34 
