Abstract:H6N6 subtype avian influenza virus (AVI) was prevalent in wild and domestic birds in Eurasian countries, and its host range is gradually expanding by adaptive mutation and gene reassortment. Phylogenetic analysis showed that this virus was one of the progenitor of the highly pathogenic avian influenza virus H5N6, as the NA segment of H5N6 virus comes from H6N6 subtype virus. Moreover, in recent years, some studies have confirmed that H6N6 subtype AIV can infect mammals, including mice, ferrets, swines and even serum specific antibodies of H6 subtype AIV was detect in healthy people. These indicate that H6N6 AIV possess the ability to cross the species barrier to infect mammals and pose a potential threat to human health.
王熹婧, 朱银川, 庞夏凤, 张增峰. H6N6亚型禽流感病毒进化演变及跨种属传播研究进展[J]. 中国人兽共患病学报, 2019, 35(6): 558-562.
WANG Xi-jing, ZHU Yin-chuan, PANG Xia-feng, ZHANG Zeng-feng. Advance in evolution and cross species transmission of H6N6 subtype avian influenza virus. Chinese Journal of Zoonoses, 2019, 35(6): 558-562.
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