Progress on the research of Treponema pallidum recombinant antigens for syphilis diagnostics
WANG Si-qian1,2, FU Bo1, ZHAO Yu-long1, LIAO Meng-jia3, LI Chang-qing4, CAO Long-gu5, ZENG Tie-bing1
1.Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang 421001, China; 2.Clinical laboratory of the First Pepole’s Hospital of Changde City, Changde 415003, China; 3.Undergraduate of Grade 2016, Clinical medicine Speciality, Hengyang Medical College, University of South China, Hengyang 421001, China; 4.Nanyue Biopharmaceutical Co., Ltd., Hengyang 421002, China; 5.College of Medical Imaging and lnspection, Xiangnan University, Chenzhou 423000, China
Abstract：Syphilis is a multistage sexually transmitted disease with complicated clinical manifestations, and serological studies remain the main method for laboratory diagnostics of syphilis. In recent ten years, serological methods, based on recombinant antigens of Treponema pallidum, considerably promoted the rapid development of treponema-specifc laboratory diagnostics of syphilis infection. However, current recombinant antigens are still inadequate for the diagnosis of early or late syphilis and for distinguishing syphilis stages or for the assessment of therapeutic efficacy. This article reviews the application value and limitations in the diagnosis of syphilis of recombinant T. pallidum lipoproteins and novel antigens including surface-exposed proteins, adhesins, and periplasmic and flagellar proteins. and summarizes the criteria for selection of optimal antigens panel, which may provide a reference for further study of other novel diagnostic antigens of T. pallidum.
王斯倩, 符波, 赵宇龙, 廖梦佳, 李长清, 曹龙古, 曾铁兵. 重组梅毒螺旋体诊断抗原的研究进展[J]. 中国人兽共患病学报, 2019, 35(9): 837-842.
WANG Si-qian, FU Bo, ZHAO Yu-long, LIAO Meng-jia, LI Chang-qing, CAO Long-gu, ZENG Tie-bing. Progress on the research of Treponema pallidum recombinant antigens for syphilis diagnostics. Chinese Journal of Zoonoses, 2019, 35(9): 837-842.
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