Abstract:To analyze the pathogenic types,drug resistance and molecular characteristics of Escherichia coli (including Enteroaggregative E.coli EAEC,Pathogenic E.coli EPEC,Enteroinvasive E.coli EIEC,Enterotoxigenic E.coli ETEC), Salmonella,Shigella and Vibrio parahaemolyticus isolated from surveillance once of food borne disease cases in Shanxi Province. The strains of Salmonella,Shigella,Vibrio parahaemolyticus and 4 kinds of E. coli isolated from food-borne diseases surveillance during 2015-2016 were collected to conduct serotyping,drug resistance test and pulsed-field gel electrophoresis (PFGE). A total of 157 stains of pathogens were isolated from 2505 diarrhea patients during 2015-2016,the overall positive rate was 6.27%.including 82 strains of E. coli (3.27%), 51 strains of Salmonella spp(2.04%),14 strains of Shigella (0.56%)and 10 strains of Vibrio parahaemolyticus(0.40%).The most prevalent E.coli strains were EPEC. In the study of 15 common antibiotic drugs,all E.coli strains were sensitive to IPM (100.0%),The sensitivity rates of CFX and TMP/SMZ were greater than 90%. The dominant serotypes were Salmoneslla typhimurium and Salmonella enteritids. All Salmonella strains were sensitive to IPM (100.0%),The sensitivity rates of CFX and CAZ were greater than 90%. All 10 parahaemolyticus isolates were tdh positive. In the active etiological surveillance for foodborne disesses in Shanxi during 2015-2016,the detection rate of E. coli was highest, then Salmonella and Shigella,the detection rate of Vibrio parahaemolyticas was lowest.