Abstract:Talaromyces marneffei is an important opportunistic fungal pathogens, which is endemic in tropical Asia, especially Thailand, northeastern India, Chinese mainland, Hong Kong, Taiwan China and Vietnam.In the past, the main population infected by T.marneffei were HIV-infected patients, while in recent years, the population of infection of T.marneffei in non-HIV-infeicted people has been increasing year-by-year. The pathogenicity of T.marneffei is related to the transformation of dimorphic switching, the formation of melanin, and the production of biochemical metabolites. Recently, there have been more in-depth studies on the pathogenesis of T.marneffei, especially the genes that regulate dimorphic switching. In this review, we summrised and reviewed current research progress of the regulation genes and other virulence genes of the metabolic products, pigmentation, morphological transformation of T.marneffei.
肖艳萍, 钟桥石, 胡龙华. 马尔尼菲篮状菌致病机制相关分子研究进展[J]. 中国人兽共患病学报, 2020, 36(1): 70-74.
XIAO Yan-ping, ZHONG Qiao-shi, HU Long-hua. The molecular research progress on pathogenic mechanism of Talaromyces marneffei. Chinese Journal of Zoonoses, 2020, 36(1): 70-74.
[1] Boyce KJ, Hynes MJ, Andrianopoulos A.The Ras and Rho GTPases genetically interact to co-ordinately regulate cell polarity during development in Penicillium marneffei[J]. Mol Microbiol, 2005, 55(5): 1487-1501.DOI:10.1111/j.1365-2958.2005.04485.x [2] Lee PP, Lau YL.Cellular and molecular defects underlying invasive fungal infections-revelations from endemic mycoses[J]. Front Immunol, 2017, 8: 735.DOI:10.3389/fimmu.2017.00735 [3] Castro-lainez MT, Sierra-hoffman M, Llompart-zeno J, et al. Talaromyces marneffei infection in a non-HIV non-endemic population[J]. IDCases, 2018, 12: 21-24.DOI:10.1016/j.idcr.2018.02.013 [4] Netea MG, Joosten LA, Van der meer JW, et al. Immune defence against Candida fungal infections[J]. Nat Rev Immunol, 2015, 15(10): 630-642.DOI:10.1038/nri3897 [5] Boyce KJ, Andrianopoulos A.Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host[J]. Fems Microbiol Rev, 2015, 39(6): 797-811.DOI:10.1093/femsre/fuv035 [6] Boyce KJ, Schreider L, Kirszenblat L, et al.The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei[J]. Mol Microbiol, 2011, 82(5): 1164-1184.DOI:10.1111/j.1365-2958.2011.07878.x [7] Nemecek JC, Wuthrich M, Klein BS.Global control of dimorphism and virulence in fungi[J]. Science, 2006, 312(5773): 583-588.DOI:10.1126/science.1124105 [8] Nimmanee P, Woo PC, Kummasook A, et al.Characterization of sakA gene from pathogenic dimorphic fungus Penicillium marneffei[J]. Int J Med Microbiol, 2015, 305(1): 65-74.DOI:10.1016/j.ijmm.2014.11.003 [9] Vanittanakom N, Cooper CR, Jr., Fisher MC, et al. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects[J]. Clin Microbiol Rev, 2006, 19(1): 95-110.DOI:10.1128/cmr.19.1.95-110.2006 [10] Zuber S, Hynes MJ, Andrianopoulos A.G-protein signaling mediates asexual development at 25 degrees C but has no effect on yeast-like growth at 37 degrees C in the dimorphic fungus Penicillium mameffei[J]. Eukaryot Cell, 2002, 1(3): 440-447. [11] Zuber S, Hynes MJ, Andrianopoulos A.The G-protein alpha-subunit GasC plays a major role in germination in the dimorphic fungus Penicillium marneffei[J]. Genetics, 2003, 164(2): 487-499. [12] Boyce KJ, Hynes MJ, Andrianopoulos A.Control of morphogenesis and actin localization by the Penicillium marneffei RAC homolog[J]. J Cell Sci, 2003, 116(Pt 7): 1249-1260. [13] Srinoulprasert Y, Kongtawelert P, Chaiyaroj SC.Chondroitin sulfate B and heparin mediate adhesion of Penicillium marneffei conidia to host extracellular matrices[J]. Microb Pathog, 2006, 40(3): 126-132.DOI:10.1016/j.micpath.2005.12.001 [14] Pongpom M, Vanittanakom P, Nimmanee P, et al. Adaptation to macrophage killing by Talaromyces marneffei[J]. Future Sci OA, 2017, 3(3): FSO215.DOI:10.4155/fsoa-2017-0032 [15] Schnell N, Krems B, Entian KD.The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism[J]. Curr Genet, 1992, 21(4/5): 269-273. [16] Dankai W, Pongpom M, Yougchim S, et al.The yapA encodes bZIP transcription factor involved in stress tolerance in pathogenic fungus Talaromyces marneffei[J]. PLoS One, 2016, 11(10): e0163778.DOI:10.1371/journal.pone.0163778 [17] Cunha MM, Franzen AJ, Seabra SH, et al.Melanin in Fonsecaea pedrosoi: a trap for oxidative radicals[J]. BMC Microbiol, 2010, 10: 80.DOI:10.1186/1471-2180-10-80 [18] Chai LY, Netea MG, Sugui J, et al.Aspergillus fumigatus conidial melanin modulates host cytokine response[J]. Immunobiology, 2010, 215(11): 915-920.DOI:10.1016/j.imbio.2009.10.002 [19] Liu D, Wei L, Guo T, et al.Detection of DOPA-melanin in the dimorphic fungal pathogen Penicillium marneffei and its effect on macrophage phagocytosis in vitro[J]. PLoS One, 2014, 9(3): e92610.DOI:10.1371/journal.pone.0092610 [20] Sapmak A, Boyce KJ, Andrianopoulos A, et al.The pbrB gene encodes a laccase required for DHN-melanin synthesis in conidia of Talaromyces (Penicillium) marneffei[J]. PLoS One, 2015, 10(4): e0122728.DOI:10.1371/journal.pone.0122728 [21] Tsai HF, Wheeler MH, Chang YC, et al.A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus[J]. J Bacteriol, 1999, 181(20): 6469-6477. [22] Woo PC, Tam EW, Chong KT, et al.High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei[J]. Febs J, 2010, 277(18): 3750-3758.DOI:10.1111/j.1742-4658.2010.07776.x [23] He Y, Li L, Hu F, et al.Expression and characterization of a Talaromyces marneffei active phospholipase B expressed in a Pichia pastoris expression system[J]. Emerg Microbes Infect, 2016, 5(11): e120.DOI:10.1038/emi.2016.119 [24] Woo PC, Lam CW, Tam EW, et al.First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei[J]. PLoS Negl Trop Dis, 2012, 6(10): e1871.DOI:10.1371/journal.pntd.0001871 [25] Sze KH, Lam WH, Zhang H, et al.Talaromyces marneffei Mp1p is a virulence factor that binds and sequesters a key proinflammatory lipid to dampen host innate immune response[J]. Cell Chem Biol, 2017, 24(2): 182-194.DOI:10.1016/j.chembiol.2016.12.014 [26] Woo PC, Lau SK, Lau CC, et al.Mp1p is a virulence factor in Talaromyces (Penicillium) marneffei[J]. PLoS Negl Trop Dis, 2016, 10(8): e0004907.