Epidemiological and clinical characteristics of 17 children with brucellosis in Hebei Province
ZHAO Meng-chuan1, LI Gui-xia2, LI Wen-hui3, ZHANG Wen-chao2, LI Mei2, DUAN Su-xia2, ZHAI Yu-lei2, GUO Ying-hui2
1.Institute of Pediatric Research, Children’s Hospital of Hebei Province, affiliated to Hebei Medical University, Shijiazhuang 050031, China; 2.Department of Laboratory Medicine, Children’s Hospital of Hebei Province, affiliated to Hebei Medical University, Shijiazhuang 050031, China; 3.Department of Infectious Diseases, Children’s Hospital of Hebei Province, affiliated to Hebei Medical University, Shijiazhuang 050031, China
Abstract:To provide a theoretical basis for clinical diagnosis and treatment, the epidemiological and clinical characteristics of children with brucellosis in Hebei Province were investigated. The epidemical features, clinical characteristics, laboratory and imaging findings, diagnosis and treatment of 17 children with brucellosis were retrospectively analyzed. Of the children with brucellosis, 70.59% were boys, 47.06% were older than 6 years old, 94.12% were from the countryside, 52.94% had exposure to cattle and sheep, and 2 cases had exposure to dogs, the first symptoms of 64.71% of children were fever of undetermined origin, the time from onset to diagnosis of 70.59% of children were less than 1 month. The most common clinical symptoms were fever, followed by joint pain or activity obstacle. The most common signs were pharyngeal hyperemia, followed by the hepatosplenomegaly, hepatomegaly or splenomegaly. No meningitis, meningoencephalitis, endocarditis and orchitis were observed. Most of the children were present with normal leukocyte and platelet count, however the lymphocytosis, anemia, elevated CRP, elevated erythrocyte sedimentation rate, elevated transaminases, and elevated creatine kinase were commonly found. Joint effusion and pulmonary texture increasing were the most common in terms of imaging findings. In conclusion, children with brucellosis in hebei province are mostly from rural areas and most of them are boys. Exposure history to cattle and sheep was most commonly observed. Most patients visited to a doctor were shown in atypical clinical symptoms with fever of undetermined origin, with or without body/joint pain.
赵梦川, 李贵霞, 李文辉, 张文超, 李梅, 段素霞, 翟玉磊, 郭映辉. 河北省17例儿童布鲁氏菌病流行特征及临床特征分析[J]. 中国人兽共患病学报, 2020, 36(2): 163-168.
ZHAO Meng-chuan, LI Gui-xia, LI Wen-hui, ZHANG Wen-chao, LI Mei, DUAN Su-xia, ZHAI Yu-lei, GUO Ying-hui. Epidemiological and clinical characteristics of 17 children with brucellosis in Hebei Province. Chinese Journal of Zoonoses, 2020, 36(2): 163-168.