Research progress of drug resistance of intestinal bacteria antibiotic resistance genes blaNDM-1 and mcr-1
LYU Dong-yue1,2,WANG Zhao-guo1,WANG Xin2
1.School of Public Health, Qingdao University, Qingdao 266021, China; 2.National Institute of Infectious Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206,China
Abstract:With the frequent use of antibacterial drugs, bacterial resistance has become one of the common concerns of global public health in the 21st century. The carbapenem antibiotic resistance gene blaNDM-1 and the polymyxin resistance gene mcr-1 have been discovered globally. Both drug resistance genes can be transferred horizontally via plasmids, posing a serious threat to humans. This article reviews the discovery, prevalence, drug resistance mechanism and detection methods of blaNDM-1 gene and mcr-1 gene, with the aim of providing a theoretical basis for the strict control of antibiotic use.
吕东月,汪照国,王鑫. 耐药基因blaNDM-1和mcr-1在肠道细菌中的研究进展[J]. 中国人兽共患病学报, 2020, 36(8): 660-664.
LYU Dong-yue,WANG Zhao-guo,WANG Xin. Research progress of drug resistance of intestinal bacteria antibiotic resistance genes blaNDM-1 and mcr-1. Chinese Journal of Zoonoses, 2020, 36(8): 660-664.
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