The effects of hydatid cyst and alveolar hydatid infection on lymphocyte subsets in Balb/c mice
CAO De-ping1, ZHANG Yao-gang2, JIANG Bo-fan3, LI Jian-hua2, PANG Ming-quan2,4, CHEN Gen1
1. Basic Medical College of Guilin Medical University, Guilin 541199,China; 2. Echinococcosis Key Laboratory of the Affiliated Hospital of Qinghai Univeristy, Xining 810001,China; 3. Clinical Lab of the Third Affiliated Hospital of Guangzhou Medical Univerisity, Guangzhou 510145,China; 4. Department of Hepatobiliary and Pancreatic Surgery of the Affiliated Hospital of Qinghai Univeristy, Xining 810001,China
Abstract:This study aimed to analyze lymphocyte subsets in spleen and blood of Balb/c mice infected by hydatid cyst and alveolar hydatid. Flow cytometry was used to analyze T, B, Th1, Th2, Treg and NK lymphocyte in spleen and blood of Balb/c mice with hydatid cyst and alveolar hydatid infection. B, Th1, Th2 and Treg cells in spleen of mice with alveolar hydatid infected group and control group were statistical difference; The difference of Th1 and Th2 cells between the alveolar hydatid infected group and the control group were statistical significance (tTh1=3.669, P<0.01; tTh2=4.302, P<0.01). B, Th1, Th2 and Treg cells in spleen of mice with hydatid cyst infected group and control group were statistical difference (tB=3.396,P<0.05;tTh1=3.539,P<0.05;tTh2=3.731,P<0.05;tTreg=2.197,P<0.05); B, NK, Th1 and Th2 cells between the hydatid cystgroup and the control group were statistical significance (tB=2.125,P<0.05;$t_{N_{K}}$=3.569,P<0.05;tTh1=6.532,P<0.05;tTh2=4.463,P<0.05). B, Th1, Th2 and Treg cells in both hydatid cyst and alveolar hydatid infected group showed the same trend. There were changes of Th1 and Th2 cells in the blood of alveolar hydatid infected group. There were changes of B, NK, Th1 and Th2 in the blood of hydatid cyst infected group.
曹得萍, 张耀刚, 姜博璠, 李建华, 庞明泉, 陈根. 细粒棘球蚴和多房棘球蚴感染对Balb/c小鼠淋巴细胞亚群的影响[J]. 中国人兽共患病学报, 2021, 37(5): 421-425.
CAO De-ping, ZHANG Yao-gang, JIANG Bo-fan, LI Jian-hua, PANG Ming-quan, CHEN Gen. The effects of hydatid cyst and alveolar hydatid infection on lymphocyte subsets in Balb/c mice. Chinese Journal of Zoonoses, 2021, 37(5): 421-425.