Abstract：The aim of the resent study was to establish a reasonable and economic model for Toxolasma gondii(T.gondii) cysts in mice in order to rovide reference for relevant study in T.gondii.Four strains of 10 female mice including C57BL/6J,ICR,KM and BALB/c were infected with 20 cysts of T.gondii RU strain,resectively.And then the number and diameter of brain cysts,as well as the mice survival rates,were observed after 42 days.Results showed that the survival rates were 100%(10/10),70%(7/10),10%(1/10) and 0(0/10) for KM,ICR,C57BL/6J and BALB /c mice,resectively.The numbers and diameters of cysts were significant different in brain tissues between ICR and KM mice(<0.01):In ICR grou,the average number of brain cysts was 1385.71±378.555 and the average diameter was 4.044±1.6175 μm;while in KM grou,the average number of brain cysts was 290.00±129.743 and the average diameter was 3.557±0.271 μm.It's suggested that the ICR mice are more suitable to serve as a model of T.gondii cysts infection than the other three strains of mice.
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