Abstract:To observe the effect of control and prevention for schistosomiasis in lake district,implementation of marshland isolation and farming prohibition or comprehensive control measures dominated by marshland isolation and farming prohibition were conducted in four heavy epidemic spots in Poyang Lake area from March 1st to October 31st every year from 1996 to 2009.The infection rates of Schistosoma for local residents,cattle and snails in each spots were also monitored for 2 to 3 consecutive years.After 2 or 3 years,the infection rates of Schistosoma for local residents,cattle and snails on these four spots have decreased significantly or even dropped to 0.In addition,there was no acute schistosomiasis case or new patient among them.It's suggested that the measure of marshland isolation and farming prohibition or comprehensive control measures dominated by marshland isolation and farming prohibition could control the transmission of schistosomiasis effectively in marshland and lake regions.