Abstract：To investigate the synergistic effect of tetrandrine(TET) to the anti-Trichophyton mentagrophytes activity of econazole(ECZ) in vivo,animal model of dermatophytosis in guinea pig was established by inoculating Trichophyton mentagrophytes conidia.These 40 infected animals were divided into 4 groups randomly and from Day 5 after inoculation,they were treated with the following formulations once per day for successive 14 days: 1% econazole and 1% tetrandrine compound cream(1%ECZ+1%TET group),1% econazole cream(1%ECZ group),1%TET cream(1%TET group) and matrix cream(matrix group).The alterations in the skin lesions and the pathological changes were observed.From the 4th day of drugs applying,the tendency of lesion score about 1%ECZ+1%TET group continued to decline.On the 14th day of drugs applying,the lesion score decreased to 0.75.There was a similarity between 1%ECZ+1%TET group and 1%ECZ group in tendency of lesion score,but more reduction was appeared in 1%ECZ+1%TET group than in 1%ECZ group(mean 0.75 VS 2.00) with obviously statistical difference(P=0.037).The culture results of skin sections and the pathological changes in 1%ECZ+1%TET group were less than those of other 3 groups.It's predicted that there is a synergistic effect of tetrandrine to the anti-Trichophyton mentagrophytes of econazole in animal model of dermatophytosis in guinea pig.
