Abstract:To understand the dynamic changes of IgM antibodies produced in mice experimentally infected with Angiostrongylus canonensis in order to evaluate the proper time for early diagnosis of angiostrongyliasis,BALB/c mice was infected with larvae of A.canonensis at III stage and the blood samples of the infected mice were taken before and after different times of infection to investigate the dynamic change of IgM antibodies by ELISA using the crude saline extract of larvae at IV-V stage as the coating antigen. It was found that the levels of the specific IgM antibodies against A.canonensis in sera of the infected mice gradually increased along with the progress of time after infection and reached its first peak 8 days after infection with a 100% of detection rate. This result suggests that detection of the IgM antibodies at the first week after infection exhibits significant value for the clinical diagnosis of angiostrongyliasis.