Abstract:To examine the antiviral effect of extract from Ceratostigma willmattianum against herpes simplex virus type-1 (HSV-1) and to assess its potential for clinical applications. Two animal models of HSV-1 infection were used by local-inoculation on the cornea and full-inoculation through tail vein of mice, and then treated with the extract from C. willmattianum with different doses. Meanwhile, ACV was employed as a positive control. The focus of the experiments was on the remedial action of C. willmattianum to HSV-1 full-infection abouta variety of viscera pathology and the time of appearance and disappearance of antigen. It was also aimed at the remedial action to herpes simplex keratitis (HSK) from the acreage variety of cornea pathological changes. Results showed that Ceratostigma willmattianum could decrease the pathological changes in viscera, and eliminate the virus antigen notably, with the effects at a dosage of 0.3 g/kg/d, equal to those of positive coutrol drug ACV. The data thus seem to indicate Ceratostigma willmattianum has remedial action to HSK.