Abstract：L.interrogans strain 56601 and L.interrogans attenuated strain have the similar genetic background but different virulence.cDNA microarrays of L.interrogans were used to analyze the differential gene expression in these two strains cultured at 37℃.The results showed that the genes expression in these two strains varied globally.Expressions of 101 genes were up-regulated significantly and expressions of 71 genes were down-regulated significantly.The differentially expressed genes belonged to twelve functional categories.The differentially expressed genes are likely to play an important role in virulence.
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