乙脑患儿血浆和脑脊液中内皮素-1含量变化及其临床意义
赵川;余光开;向光明;
泸州医学院附属医院感染科,泸州医学院附属医院感染科,广元市人民医院感染科 泸州646000,泸州646000
The changes and clinical significance of Endothelin-1 in plasma and cerebrospinal fluid in children with epidemic encephalitis B
摘要 目的探讨内皮素(ET)与流行性乙型脑炎的关系。方法采用放射免疫分析(RIA)法检测52例乙脑患儿血浆及脑脊液中内皮素-1(ET-1)含量。结果乙脑患儿极期血浆及脑脊液中ET-1含量均明显高于对照组(P<0.001),有显著统计学意义。重型乙脑患儿血浆及脑脊液中的ET-1含量均值明显高于普通型乙脑患儿(血浆P<0.01,脑脊液P<0.05)。结论血浆及脑脊液中ET-1含量增高与脑实质损伤程度密切相关,其含量增高可作为脑实质损伤程度的一个重要指标。
关键词 :
流行性乙型脑炎 ,
内皮素-1 ,
血浆 ,
脑脊液
Abstract :To study the relationship between endothelin-1(ET-1) and epidemic encephalitis B in children,the level of ET-1 in plasma and cerebrospinal fluid was measured in 52 patients with epidemic encephalitis B by using the radioimmunoassay(RIA).It was found that the level of ET-1 was significantly higher in epidemic encephalitis B than that of controls group(P<0.001).and the average value of severe type in the patients with epidemic encephalitis B was significantly higher than that of common type(plasma P<0.01,cerebrospinal fluid P<0.05).That is to say,the level of ET-1 is elevated in plasma and cerebrospinal fluid of epidemic encephalitis B and it is relate to the degree of parenchyrnal lesions of brain.These reseachs suggest that the elevation of ET-1 may be an important marker of the parenchymal lesions of brain in patients with epidemic encephalitis B.
Key words :
Epidemic encephalitis B
Endothelin-1
Plasma
Cerebrospinal fluid
收稿日期: 2006-01-20
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