深圳市人民医院(暨南大学医学院第二附属医院)临床医学研究中心,华中科技大学同济医学院寄生虫学教研室
,兰州医学院寄生虫学教研室
,Universite d eFranche-comte,Division of Biological,the University of Salford 深圳,518020
,France
,UK
Observation of lymphocyte from hosts with alveolar echinococcosis
Abstract:Aim To explore the immunological regulation mechanism of host infected with alveolar echinococcus Methods The course of the infection was followed for 25 weeks,spleen cell from BALB/c mice infected with AE,CD + 4 and CD + 8 levels were determined by flow cytometry Expression of CD + 3,CD + 4,CD + 8,CD + 19 ,CD + 38 ,CD + 56 ,HLA DR + from 25 cases with AE was analyzed by flow cytometry Results 1-8 weeks of post infection,the CD + 4 cell showed a increase,and then decrease,which the CD + 8 cell gradually increased throughout the period after BALB/c mice was infected with AE There was a significant drop down that CD + 4/CD + 8 ratio since 20 weeks of post infection(P<0 05) CD + 4cells from patients with AE was significantly lower than that of control group(P<0 05),CD + 8 cells was significantly higher than that of control group(P<0 05) CD 56 +cells and CD + 4/CD + 8 ratio were remarkably decrease as compared with the controls(P<0 05),Conclusion CD 4 is mainly response in the early stage of infection,CD 4 response is replaced by CD 8 response in later period of infection AE patients exhibit a immune inhibition response,the immune inhibition response is very useful to patients with chronic alveolar echinococcus infection