Abstract：Aim To observe the effect of Vitamin B 6 on reduction of the main side effects of Praziquantel for schistosomiasis.Methods Villagers aged 6-60 in 328 endemic villages were selected and divided into experimental and control groups.The experimental group were given single oral dose of both praziquantel and Vitamin B 6,while the control group were given single oral dose of praziquantel and placebo.The dosages of praziquantel were,body weight limit being below 60 kg.45mg /kg for those of 6-14 years old and 40mg/kg for those aged 15-60.Dosages of Vitamin B 6 were 20mg per capita for those of 6-14 years old and 30mg/kg per capita for those aged 15-60.Results Occurrence rate of praziquantel side effects in the experimental group and in the control group were 73 78% and 81 10% respectively,showing significant difference (P<0.05).The Occurrence rates of main side effects on the nervous and digestive systems were 72.86% in the experimental group and 79.57% in the control group respectively,also indicating significant difference (P<0.05).By contrast of disappearance time of dizziness within 2,4,6,8,and 10 hours,the accumulated disappearance rate of side effects of the experimental group was obviously higher than that of the control group.Conclusion Vitamin B 6 is effective in reducing occurrence rate of the main side effects of Praziquantel for schistosomiasis and speeding up the disappearance time of dizziness.
