Abstract:Aim To explore the differences and clinic value of the different detective methods for Helicobacter pylori(Hp). Methods Detecting anti-Hp-IgG antibody in blood and saliva of patients with DIGFA.Decting Hp infection in biopsy specimen of gastric mucosa with RUT and PCR-Hp-DNA at the same time.Results The anti-Hp-IgG antibody in blood, anti-Hp-IgG antibody in saliva, RUT in gastric mucosa and PCR-Hp-DNA in gastric mucosa, the positive rate was 84%, 58%, 59%, 62%, respectively, while the correct rate for diagnosing Hp infection is 72.72%, 90%, 91%, 92%.The sensitivity is 94.64%, 85.71%, 87.50%, 94.64%. The specificity was 35.29%, 97.06%, 97.06%,91.18%. The positive predictive rate was 70.67%, 92.31%, 92.45%, 94.64%. The negative predictive rate is 80.00%, 86.84%,89.19%, 91.18%. Conclusions The correct rate, sensitivity and specificity of anti-Hp-IgG in salviva with DIGFA are similar to gastric mucosa with RUT. Both of these two methods are non-invasive, simple, rapoid, cheap and adaptable to clinic test. Anti-Hp-IgG antibody in blood is suitable for epidemic investigation. PCR-Hp-DNA is suitable for scientific researches.