Abstract:The pure organis-ms of Candida albicans have been isolated from the deep layer tissue of lesions during investigating the causetive pathogen of rot foot in 1582 cases of cattle in the epidemic fields.By the organism Candida albicans more animals in experiment have fallen ill with histopathology and clinical symptom as same as natural cases without specific condition to be inoculated.The saprophytic organisms of ulcer were not agglutinated to positive sera,prepared both by natural cases and inoculation,detecting the samples of sera from epidemic and normal fields,the positive rate was 75.5% to 93% in epidemic fields higher than 6% to 21% in normal fields,It was very marcked difference to contrast with both B and C.antigens prepared by C.albicans from buffalo and cattle.The immunoglobulin,seperated from out of antibody against C.albicans labelled by FITC to survey the phagocytes of body fluid of 195 cases in serious epidemic districts,have been discovered fluorochrome approximate 76% with direct fluorecent antibody test.Identification of these experiments could be demonstraed that C.albicans was the pathogen of rot foot of cattle.In the early stages of disease,could be cured by oral with these mycostat such as potassium iodine and nystatini.