Efficacy on different kinds of drugs against acute murine toxoplasmosis
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science,
Key Laboratory for Animal Parasitology of Ministry of Agriculture, Shanghai 200241, China
Abstract：In order to identify more effective and less toxic drugs to treat animal
toxoplasmosis, nine different kinds of drugs against T. gondii in an acute murine model were
evaluated respectively. Then, the efficacy of the ideal drug SPZ was evaluated further
through the different dosage and being combined with PM. The mice used throughout the study
were randomly assigned to many groups (12 mice each), which either remained uninfected or
were infected intraperitoneally with tachyzoites of T. gondii (strains RH, 5 000 organisms).
Of 24 hours after infection, mice were administered with drugs at a moderate dosage for 5
days, according to the animal's body weight. Mice were observed for 40 days after infection.
The factors of average survival days, timepoint of 50% fatalities and survival rate showed
the efficacy of drugs. The results indicated that SPZ was the best drug against the
parasites with better data compared with other drugs groups (P<0.05). Also, it showed SPZ
(250mg/kg) and the combination of SPZ (350mg/kg) and PM (15mg/kg) protected almost 58.33%
and 54.55% mice from death respectively. The average survival time and the timepoint of
50% fatalities were prolonged significantly compared to SD group and other treated groups
(P<0.05). The results suggest that SPZ seems to be a more efficacious drug in the treatment
of T. gondii in an acute murine model. The drug may be a promising drug candidate for the
treatment and prevention of toxoplasmosis in animals and lay a foundation for further
research.
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2011, Vol. 27 
