Abstract:ABSTRACT: To observe the dynamic chance of immune response in mice infected with Angiostrongylus cantonensis at difference period of time, and to explore host’s immune regulation. The infection lasted and was followedup for 18 days. And determinded IL-2、L-4 and specific IgG subclasscs by ELISA. In this way, The IL-2 level appeared low level after infected with Angiostrongylus cantonensis. The level of IL-4 decrease in 7 days of infection, and showed a nadir at the 7th day, subsequently increase gradually. IgG1 showed high level, and IgG2a appeared no change following infection. The results indicated that the cell immunity function was weak and the humoral immunity function reinforced in the BALB/c mice after infected Angiostrongylus cantonensis.