Abstract：The purpose of this study was to investigate the expression on intracellular
proteins of IL13Rα2 in the macrophages of Schistosomiasis japonicum mice, and to offer
the experiment foundation for elucidating IL13 responding cell and mechanism of
fibrogenesis in Th2mediated diseases. A large number of mice were exposed to cercariae and
established S. japonicum mouse model. IL13Rα2 expressed in the granulomas of liver
tissues and peritoneal macrophages was determined by immunofluorescent labeling with primary
antibody of goat antimouse IL13Rα2 antibody and monoclonal antiCD68 antibody,
respectively. Coffee beanlike IL13Rα2 positive staining was showed in the hepatic
granuloma in fluorescentmicroscopy. Coexpression of IL13Rα2 and CD68 protein in
peritoneal macrophages from 8week infected mice was observed. It exhibited the
distribution of IL13Rα2 in cytoplasm concentrated on the inner layer of membrane in
macrophages. It’s suggested that IL13Rα2 expressing macrophages might be a critical
contributor to the immunopathogenesis of schistosomiasis.
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2011, Vol. 27 
