Abstract：The aim is to evaluate the efficacy of high intensity focused ultrasound (HIFU) combined with ultrasound contrast agent (UCA) on hydatid cysts of Echinococcus granulosus in vitro, and obtain a better method of HIFU which would be used to kill the cysts. One hundred and fifty fresh cysts were divided into 6 groups according to the diameters of cysts, and every group was received following treatments respectively: Group A (blank control) without HIFU treatment; Group B treated with 0.1 μl UCA only; Group C treated with HIFU only; Group D treated with 0.1 ml UCA and HIFU; Group E treated with 0.2 ml UCA and HIFU. During the irradiation of HIFU, the changes of ultrasonic gray scale of the cysts were recorded accordingly, and the instant death rates of protoscoleces were determined from the hydatid fluids. It was demonstrated that the changes of ultrasonic gray scale and the instant death rate of protoscoleces treated with UCA and HIFU were significant than those in the groups treated with HIFU only, or UCA only, and the changes were obvious in the groups treated with the increase of UCA. Those results suggest that UCA could enhance the killing efficacy of HIFU on hydatid cyst in vitro.
收稿日期: 2012-01-21
出版日期: 2013-01-06
基金资助:SAR与UCA及ABZ脂质体协同下的高强度聚焦超声杀灭细粒棘球蚴的研究
通讯作者:
叶彬
E-mail: yebina@sohu.com
引用本文:
蔡辉 张静 叶彬. 微泡造影剂对高强度聚焦超声杀伤离体棘球蚴的增强作用[J]. 中国人兽共患病学报, 2012, 28(12): 1202-1206.
Jing ZHANG. Effects of high intensity focused ultrasound combined with ultrasound contrast agent on hydatid cysts in vitro. Chinese Journal of Zoonoses, 2012, 28(12): 1202-1206.
2012, Vol. 28 
