Abstract:Abstract: To analyze the epidemic characteristics and influence factors of Japanese B Encephalitis(JE) in different areas of Henan Province. The epidemic situation information of JE in Xinyang and Luoyang city from 2004 to 2010 were statistically analyzed by SPSS 12.0 and Excel 2003 software. Xixian of Xinyang city and Xin’an of Luoyang city were chosen as monitoring sites.Healthy people of these two cities were selected to eight age groups. The blood samples of them were gathered in May and November and the JE neutralizing antibody was detected by MCPENT.At the same time, the mosquito specimens were gathered with labor hour method and mosquito net method, the mosquito density was calculated once every month from May to October. From 2004 to 2010, the annual average incidence rate of JE incidence was 1.97/100,000 and the annual average mortality rate was 2.92% in Xinyang city, 1.01/100,000 and 9.73% in Luoyang city.91.47% of total cases in Xinyang were occurred from July to August. 84.29% of total cases in Luoyang were occurred from August to September.97.52% of patients in Xinyang were in < 14-year-old age group,57.08% of patients in Xinyang were in ≧ 15-year-old group.Age structure of two city had statistical significance. ( 2=557.71, P <0.05)Most patients were scattered children (68.36%) in Xinyang and farmers(46.46%) in Luoyang.The peak of mosquito density appeared from June to July in Xinyang,the density was 25.09 per labor hour in June and 27.31 in July.The peak of mosquito density appeared from July to August in Luoyang,the density was 13.94 per labor hour in July and 14.12 in August.The JE neutralizing antibody positive rate of ≧ 15-year-old age group is 97.78% in Xinyang, and 48.94% in Luoyang ,The two rates had statistical significance. ( 2=55.42,P<0.05). The peak of incidence of JE in Xinyang was one month early than luoyang, This is consistent with the peak of mosquito density in Xinyang was one month early than luoyang.The primary patients were in 0~ 14-year-old age group in Xinyang.The primary patients were in ≧ 15-year-old group in luoyang.This is consistent with the difference between The JE neutralizing antibody in two cities.Taking different incidence method in different time is the key to reduce the incidence of the younger groups in Xinyang and luoyang, and the incidence of the older age group in luoyang.