Abstract:ABSTRACT:To investigate the effect of fluridone, an inhibitor of abscisic acid, on mice infected with Toxoplasma gondii RH strain, the mice infected with T.gondii were treated with fluridone by intraperitoneal injection, and observed the survival time and the weight reduction rate of them. The modality of T.gondii in the intraperitoneal cavity of mice were observed by microscope and electron microscope, and the irradiation of T.gondii were evaluated by tissue slice printing. The symptom of toxoplasmosis in mice group treated with fluridone appeared later and milder than that of the control group. The survival duration was longer(P<0.05)and the extension rate was 45%. The weight inhibitory rate of the treated mice was 6.13%, whereas that was 7.23% in the control mice. T.gondii in the control group were tachyzoites mainly, but intracellular parasite in mice treated with fluridone. The organs of the mice infected with T.gondii later and the degree of infection was mild than the control. These results suggested that fluridone could inhibit toxoplasmosis in mice, which were related to the blocking T.gondii egress and inducing development of vaculoes intracellular by inhibiting abscisic acid.