Abstract：The apical membrane antigen-1 (AMA-1) is highly expressed in the late schizont stage of the Plasmodium and plays an important role in the merozoite adhesion and invasion of erythrocytes. Recent researches for Plasmodium were carried on the molecular biology and immunology. These researches show that AMA-1 is a leading malaria vaccine candidate antigen. This article gave a detailed introduction about molecular structure and polymorphism of the Plasmodium falciparum AMA-1 genes and emphasisly analysed some important domains of AMA-1 gene, groups of gene families and the reason of polymorphism to provide the reference for the further study of polymorphism of AMA-1 gene.
周银发，张山鹰. 恶性疟原虫AMA-1基因多态性研究进展[J]. 中国人兽共患病学报, 2013, 29(2): 187-190.
ZHOU Yin-fa , ZHANG Shan-ying. Advances on research of AMA-1 gene polymorphisms in Plasmodium falciparum. Chinese Journal of Zoonoses, 2013, 29(2): 187-190.
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