Association between Chlamydia pneumonia infection and Alzheimer’s disease
YANG Xin-ling1, LIU Xue-qing1, YANG Jie-min2
1.College of Laboratory Medicine, Hebei North University, Zhangjiakou 075000, China; 2.Department of Neurosurgery, the Second People’s Hospital of Yunnan Province, Kunming 650021, China
Abstract：Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, whereby it is customary to distinguish between early familial FAD and late-onset AD (LOAD). The importance of inflammation in the pathogenesis of LOAD is increasingly being recognized and many studies show that Chlamydia pneumonia (Cpn) has been implicated in LOAD pathogenesis. This review focuses specifically on infection with Cpn in LOAD including the histopathological basis, animal model research and antibiotic treatment studies, and how the infection may function as a “trigger or initiator” in the pathogenesis of LOAD.
杨新玲，刘雪晴，杨杰民. 肺炎衣原体感染与阿尔茨海默病的关系[J]. 中国人兽共患病学报, 2013, 29(2): 195-198.
YANG Xin-ling, LIU Xue-qing, YANG Jie-min. Association between Chlamydia pneumonia infection and Alzheimer’s disease. Chinese Journal of Zoonoses, 2013, 29(2): 195-198.
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