Abstract:The objective of the present study was to summarize and analyze the epidemics of human rabies in Guangxi, China, from 1951 to 2010, and to investigate the epidemiological factors and the features for providing scientific evidence for development of the prevention and control strategies. A descriptive epidemiological method was used to conduct statistical analysis on the epidemiological data of rabies and reported cases in Guangxi between 1951 and 2010. Totally, 17 210 cases of human rabies were reported during these 60 years and the overall incidence was high. The epidemic peak appeared around every 10 years from 1951. The epidemic focus was expended annually, from the north to the south and from the east to the west. Most of cases were found in rural areas, being caused by dog bites with category Ⅲ exposure mainly in head, face and upper limb. The average latent period was 63 days. Though provided by proper postexposure treatment, some patients still died during or after rabies vaccination. Statistical data from surveillance site of human rabies exposure clinics showed that the morbidity was 2.75/100 000. In the year from 2006 to 2010, the positive rates of nucleic acid of rabies virus in brain tissues of the dogs with healthy appearance were 1.9%, 0.93%, 0.91%, 0.40% and 0.00%, respectively. Results suggested that prevalence of human rabies is high in Guangxi and shows a periodic epidemic situation. The factors including keeping large number of dogs, low vaccination rate in dog, high rate of virus carrying among healthy appearance dogs, high exposure rate of human to dogs, low awareness of self-protection, and the unaffordable cost of vaccination are all contributed to the epidemics. The continued expansion of natural epidemic focus, inadequate management of infection source, and inadequate implementation of comprehensive prophylaxis are the main reasons for the reemerging of human rabies in Guangxi.
杨进业,莫毅,谭毅,莫兆军,莫建军,周开姣. 广西1951-2010年狂犬病流行特征分析(英文)[J]. 中国人兽共患病学报, 2013, 29(3): 294-299.
YANG Jin-ye,MO Yi,TAN Yi,MO Zhao-jun,MO Jian-jun,ZHOU Kai-iao. Epidemiology of human rabies in Guangxi, China,1 951-2010. Chinese Journal of Zoonoses, 2013, 29(3): 294-299.
[1] Mo Y, Mo ZJ, Liu B, et al. A cross-sectional study on knowledge, attitude and practice regarding rabies on rural residents in Guangxi\[J]. Appl Prev Med, 2010, 16(6): 343-345. (in Chinese) 莫毅,莫兆军,刘波,等.广西人群狂犬病知识、态度及行为调查\[J].应用预防医学,2010,16(6):343-345. [2] Zhang YZ, Xiao DL, Sun YH, et al. The epidemic situation of human rabies from 1984 to 2002 and its preventive measures in China\[J]. Chin J Epidemiol, 2003, 24(10): 883-886. (in Chinese) 张永振,肖东楼,孙玉辉,等.中国1984-2002年狂犬病流行情况及防制对策\[J].中华流行病学杂志,2003,24(10):883-886. [3] Lu JH, Wu TC. Epidemic status and evaluation on the effects of control of rabies in Guangxi during the past 45 years\[J]. Chin J Epidemiol, 1997, 12(11): 408-411. (in Chinese) 陆家华,吴泰才.广西45年狂犬病疫情动态与防制效果分析\[J].疾病监测,1997,12(11):408-411. [4] Song M, Tang Q, Xu Z, et al. Analysis on the factors related to rabies epidemic in China, in 2005\[J]. Chin J Epidemiol, 2006, 27(11): 956-959. (in Chinese) 宋淼,唐青,许真,等.中国2005年狂犬病流行相关因素分析\[J].中华流行病学杂志,2006,27(11):956-959. [5] Liu YW, Li W, Lu YJ, et al. Epidemiological survey of 505 rabies cases in Yulin City, Guangxi Autonomous Region\[J]. Dis Surveill, 2009, 24(10): 757-760. (in Chinese) 刘义威,李文,卢耀娟,等.广西玉林市505例狂犬病流行病学调查\[J].疾病监测,2009,24(10):757-760. [6]Cliquet F, Aubert M. Elimination of terrestrial rabies in Western European countries\[J]. Dev Biol (Basel), 2004, 119:185-204. [7] Gu SW, Xu GL, Wu TC, et al. Experimental study on rabies virus carried by home bred dog in Guangxi\[J]. Guangxi Prev Med, 2003, 9(1): 1-4. (in Chinese)古绍文,徐葛林,吴泰才,等.广西家犬携带狂犬病毒的实验研究\[J].广西预防医学,2003,9(1): 1-4. [8] Zhang ZM, Li LH, Kang M, et al. Analysis on the factors related to rabies epidemic in Guangdong, in 2008\[J]. South China J Prev Med, 2009, 35(6): 38-40. (in Chinese) 张正敏,李灵辉,康敏,等.广东省2008年狂犬病病例流行病学及危险因素分析\[J].华南预防医学,2009,35(6):38-40. [9] Liu FQ, Gao LD, Guo SH, et al. Analysis on incubation period of human rabies and its influential factors in Hunan province from 2004 to 2007\[J]. Modern Prev Med, 2010, 37(7): 1213-1216. (in Chinese) 刘富强,高立冬,郭绶衡,等.湖南省1059例狂犬病例潜伏期长短及其影响因素分析\[J].现代预防医学,2010,37(7):1213-1216. [10]Wu TC, Gu L, Wang SS, et al. The investigation report on early death of rabies\[J]. Guangxi Med J, 1989, 11(1): 63-66. (in Chinese) 吴泰才,古漓,王树声,等.狂犬病“早死”现象调查报告\[J].广西医学,1989,11(1): 63-66. [11] Yu YX. Rabies and rabies vaccine\[M]. Beijing: Chinese Medicine Science Press, 2001: 36. (in Chinese) 俞永新.狂犬病和狂犬病疫苗\[M].北京:中国医药科技出版社,2001:36. [12] Wang SS, Wu TC, Gu L, et al. Prevention and control of rabies\[M]. Nanning: Guangxi Science Technology Press, 1993: 11-25. (in Chinese) 王树声,吴泰才,古漓,等.狂犬病的预防与控制\[M].南宁: 广西科学技术出版社,1993:11-25. [13] Yang JY, Xie YH, Mo ZJ, et al. Epidemiological survey on early death of rabies in Guangxi from 2003 to 2004\[J]. Guangxi Prev Med, 2005, 11(3): 143-146. (in Chinese) 杨进业,谢艺红,莫兆军,等.2003-2004年广西狂犬病早死现象的研究\[J].广西预防医学,2005,11(3):143-146.