Progress on laboratory diagnostic methods of pathogenic Clostridium spp. infection
TIAN Li-na,CHENG Ying,LU Jin-xing
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable 2.Disease Control and Prevention, Chinese Center for Disease Prevent and Control, Beijing 102206, China
Abstract: Pathogenic Clostridium spp. are some species of Clostridium prazmowski which can cause infectious diseases in animal and human being, mainly including C. botulinum, C. difficile, C. perfringens, and C. tetani. The diseases caused by Clostridium spp. are important zoonoses with serious symptoms and high mortality usually. The conventional methods for detecting and identifying the bacteria are time-consuming and need the operating personnel of high technical requirements. In recent years, lots of immunoassays and molecular biotechnology methods have been developed and widely used for the detection of Clostridium infections because of the short turnaround time and their high sensitivity. In this paper, the recent researches on laboratory diagnosis methods of pathogenic Clostridium spp.are reviewed, providing the reference of clinical diagnosis and epidemiological investigation on Clostridium infections
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