Abstract:ABSTRACT: To explore the influencing factors of kala-azar in the foci of desert-type kala-azar, a 1:3 matched case-control study was conducted on 21 cases of kala-azar and 63 matched controls from Jiashi County, Xinjiang Uygur Autonomous Region. Healthy children were chosen as controls under the following criterion: in the same village, the same gender and similar age within one year with cases, without the history, symptoms and signs of kala-azar, and negative results with rK39 dipsticks. Using SPSS 17.0 software, the potential influencing factors including habits, living environment and behavior were analysed by univariate and multivariate conditional logistic regression. The univariate conditional logistic regression analysis showed that the distance between bedrooms and enclosures of livestock and kala-azar patients in home or neighbours in the last two years were significantly different between groups of cases and controls (P<0.05). The multivariate analysis showed that the number of domestic animals and the distance between bedrooms and enclosures of livestock were incorporated in the multivariable models with their interaction being significantly different (P<0.05). The factors of the number of domestic animals and the distance between bedrooms and enclosures of livestock are influencing factors of kala-azar in the foci of desert-type kala-azar.