Abstract：Bioinformatics research about the WD40 domain contained protein family of Cryptosporidium parvum was conduct in this study, and then structure analysis of the WD40 domain and its function prediction would provide some basic theory for Cryptosporidium parvum gene function studies. Firstly, based on the data collection, we acquired WD40 domain contained protein family's sequences. Then the CDD domain search and alignment analysis were conducted through the NCBI for every protein to ensure that all of them were WD40 domain contained proteins. Lastly, we processed the domain analysis and functional prediction. So, we obtained 50 domain contained proteins of C. parvum Iowa II, and found that there were significant differences among their amino acid sequence length, molecular weight, isoelectric point, etc. And from domain analysis, cgd1_1930, cgd5_740 and cgd4_3360 contains CAF1C_bd super family, which may be involved in DNA repair and replication; cgd4_260 contains ACE1-Sec16-like super family, which may be involved in vesicle formation and material transport; cgd1_2600 contains TAF5_NTD2 domain, which may involved in protein-protein interactions. It's suggested that the WD40 protein family may not only play a role in the interaction alone, but also exert their biological effects through it.
陈川，荆春霞，张鲍欢，张丽菊，黄伟煌，井立鹏，东方，杨光. 基于生物信息学分析微小隐孢子虫含WD40结构域的蛋白功能[J]. 中国人兽共患病学报, 2014, 30(6): 583-587.
CHEN Chuan,JING Chun-xia,ZHANG Bao-huan,ZHANG Li-ju,HUANG Wei-huang,JING Li-peng,DONG Fang, YANG Guang. Function of proteins with WD40 domain in Cryptosporidium parvum based on bioinformatics. Chinese Journal of Zoonoses, 2014, 30(6): 583-587.
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2014, Vol. 30 
