Recombinant protein of Echinococcus granulosus EG95
LI Hong-min1,2,LOU Zhong-zi1,LI Li1,LI Zhen-hua2,LI Jian-qiu1,YAN Hong-bin1,JIA Wan-zhong1
1.State Key Laboratory of Veterinary Etiological Biology / Key Laboratory of Veterinary Parasitology of Gansu Province /Key Laboratory of Veterinary Public Health of Ministry of Agriculture/ Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; 2. Weifang Food Valley Academy of Animal Husbandry Co., Ltd., Weifang 261000, China
Abstract:Echinococcosis (hydatid disease) caused by the metacestodes of Echinococcus granulosus tapeworm is a serious zoonotic infection, which leads to a large amount of economic loss in human and animals. It needs to be prevented urgently. The EG95 protein is highly conserved and crucial for survival and development of E. granulosus in the host, which means that it is one of the potential candidate antigens for vaccines characterized so far. Great effort has been made to construct and express the recombinant EG95 (rEG95) gene in various kinds of expression systems in order to obtain an efficient defined antigen. This review will summarize research progress on expression of rEG95 in different vector systems.
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