Abstract:In this study, we investigated the prevalence of HIV-1 drug resistance among patients infected with HIV through sex behaviour who were receiving highly active anti-retroviral therapy (HAART) in Hebei Province. Plasma samples were collected from patients who were infected with HIV through sex behaviour. Then the detection of HIV-1 genotype was implemented, and HIV drug-resistance mutations were analyzed. Results indicated that 68 of 231 patients, infected with HIV-1 by sex transmission, occurred drug-resistance mutation. The rate of the drug resistance was 29.44% (68/231). The rate of resistance to RTs (29.00%, 67/231) was much higher than that of PIs (0.87%, 2/231). Therefore, the main causation which resulted in therapic failure was drug-induced mutation. The detection of HIV drug resistance throughout HAART was useful so that we could make the better plan of highly active anti-retroviral therapy (HAART).
路新利,赵宏儒,王伟,赵翠英,白广义,张玉琪,李岩,王莹莹,陈素良. 性传播艾滋病患者抗艾滋病毒治疗后的HIV-1pol区基因突变研究[J]. 中国人兽共患病学报, 2015, 31(1): 53-56.
LU Xin-li,ZHAO Hong-ru,WANG Wei,ZHAO Cui-ying,BAI Guang-yi, ZHANG Yu-qi,LI Yan,WANG Ying-ying,CHEN Su-liang. HIV-1 RNA pol gene mutation among patients infected with HIV through sex behaviour after antiretroviral therapy. Chinese Journal of Zoonoses, 2015, 31(1): 53-56.
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