In vitro study on the synergistic effect of tetrandrine to itraconazole, voriconazole and posaconazole against Aspergillus fumigatus
LI Shui-xiu1, SONG Yan-jun1, SHI Jian-ping1, 2, GUO Hui1, ZHANG Ling-ling1, ZHANG Hong1
1.First Affiliated Hospital and Institute of Mycology, Jinan University, Guangzhou 510632, China; 2.Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University, Shenzhen 518000, China
Abstract：The purpose of this study is to investigate the synergistic effect of itraconazole (ITR), voriconazole (VRC) or posaconazole (PCZ) alone and in combination with tetrandrine (TET) against Aspergillus fumigatus. We investigated the in vitro antifungal effects of ITR/VRC/PCZ alone and in combination with TET against 23 clinical isolates of A. fumigatus using the microdilution method described in M38-A. The minimum inhibitory concentrations (MIC s) of ITR alone and combined with TET against the A. fumigatus were 0.5-32 μg/mL and 0.0625-4 μg/mL, respectively (P<0.05 ); the MIC s of VRC alone and combined with TET against the A. fumigatus were 0.25-2 μg/mL and 0.031 25-0.25 μg/mL , respectively (P<0.05 ); the MIC s of PCZ alone and combined with TET against the A. fumigatus were 0.125-1 μg/mL and 0.031 25-0.25 μg/mL , respectively (P<0.05 ). Thus, TET acts synergistically with ITR/VRC/PCZ against A. fumigatus in vitro.
李水秀, 宋延君, 石建萍, 郭慧, 张玲玲, 张宏. 汉防己甲素对伊曲康唑、伏立康唑和泊沙康唑抗烟曲霉体外增效活性研究[J]. 中国人兽共患病学报, 2015, 31(5): 408-411.
LI Shui-xiu, SONG Yan-jun, SHI Jian-ping, GUO Hui, ZHANG Ling-ling, ZHANG Hong. In vitro study on the synergistic effect of tetrandrine to itraconazole, voriconazole and posaconazole against Aspergillus fumigatus. Chinese Journal of Zoonoses, 2015, 31(5): 408-411.
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