New advances on studies of biological functions and immunogenicity of Toxoplasma gondii dense granule proteins
HU Ling-ying1, 2, ZHANG Nian-zhang2, WANG Jin-lei2, LIN Xuan1, ZHOU Dong-hui2, ZHU Xing-quan2, WANG Shou-kun1
1.College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 2.State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Abstract：Toxoplasma gondii can cause zoonotic toxoplasmosis, and is a serious threat to public health. Dense granule is one of the three major secretory organelles in T. gondii cytoplasm, which can maintain and adjust the functions of parasitophorous vacuole (PV) and parasitophorous vacuole membrane (PVM). Some of the dense granule proteins (GRAs) can regulate the host genome expression. In recent years, more new GRA proteins have been identified and many studies have focused on potentially important anti-T. gondii vaccine candidate molecules. In this review, we summarize new advances and perspectives in studies of biological functions and immunogenicity of T. gondii GRAs in recent years, which would provide useful information for further studies of pathogenesis of toxoplasmosis and development of novel vaccines against T. gondii infection.
胡玲英, 张念章, 王金磊, 林旋, 周东辉, 朱兴全, 王寿昆. 弓形虫致密颗粒蛋白的生物学功能及免疫原性研究的新进展[J]. 中国人兽共患病学报, 2015, 31(7): 663-668.
HU Ling-ying, ZHANG Nian-zhang, WANG Jin-lei, LIN Xuan, ZHOU Dong-hui, ZHU Xing-quan, WANG Shou-kun. New advances on studies of biological functions and immunogenicity of Toxoplasma gondii dense granule proteins. Chinese Journal of Zoonoses, 2015, 31(7): 663-668.
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2015, Vol. 31 
