Geographical distribution of hepatitis E virus genotypes and subtypes in China
LIU Min1, 2, LI Li-juan1, XIAO Wen2
1.School of Public Health, Dali University, Dali 671000, China; 2.Institute of Eastern-Himalays Biodiversity Research, Dali University, Dali 671003, China
摘要 戊型肝炎病毒(Hepatitis E Virus,HEV)是通过肠道传播,属于戊型肝炎病毒科戊型肝炎病毒属.从分子水平上看,HEV是一种无包膜的单股正链RNA病毒.它既可以引起戊型肝炎急性散发病例,也可以造成大规模暴发流行.在孕妇中,戊型肝炎的病死率可高达20%.随着基因测序技术的快速发展,通过对HEV进行全基因或部分基因的测序,至少可以把HEV分为4种基因型,且有明显的地理分布特征.从世界范围来看,基因Ⅰ型主要分布于亚洲和非洲;基因Ⅱ型局限分布在墨西哥和非洲;基因Ⅲ型广泛分布于世界各地;基因Ⅳ型主要分布于亚洲国家.本文通过查阅有关中国HEV基因型文献,对中国HEV基因型及其亚型的地理分布进行梳理.
Abstract:Hepatitis E virus is a pathogen spread through the intestine and belongs to the hepevirus of the hepeviridae. Judging from the molecular level, HEV is a non-enveloped single-strand RNA virus. It not only can cause sporadic cases of acute hepatitis E, but also can cause large-scale outbreaks. In pregnant women, hepatitis E mortality can be as high as 20%. With the rapid development of gene sequencing technology, HEV can be at least divided into four genotypes by sequencing its whole gene or partial gene and it has obvious geographical distribution. From a global perspective, genotypeⅠis mainly in Asia and Africa. GenotypeⅡis confined in Mexico and Africa. Genotype Ⅲ is widely distributed around the world. Genotype Ⅳ is mainly in Asian countries. In this paper, we will review all the literature on HEV genotypes in China in order to sort out the geographical distribution of HEV genotypes and subtypes and provide a reference for the study of hepatitis E in different regions of China.
刘敏, 李丽娟, 肖文. 中国戊型肝炎病毒基因型及其亚型的地理分布[J]. 中国人兽共患病学报, 2016, 32(2): 182-187.
LIU Min, LI Li-juan, XIAO Wen. Geographical distribution of hepatitis E virus genotypes and subtypes in China. Chinese Journal of Zoonoses, 2016, 32(2): 182-187.
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