Abstract：Zika virus disease is caused by Zika virus transmitted by Aedes mosquitoes. It is a mild disease and most people with the virus do not have symptoms. Potential complications of Zika virus disease might be babies born with microcephaly and Guillain-Barré syndrome. Zika virus diagnosis can be confirmed by laboratory testing for the presence of Zika virus RNA in the blood or other body fluids, such as urine or saliva. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus was first identified in humans in Uganda in 1952. Outbreaks of Zika virus disease have been recorded in Africa, the Americas, Asia and the Pacific.
[1] National Health and Family Planning Commission of the People's Republic of China. Notification for diagnosis and treatment plan of Zika virus disease[EB/OL].(2016-02-03)[2016-03-15].http://www.nhfpc.gov.cn/yzygj/s3593g/201602/e7c1402a03024501ad8f036de346c145.shtml(in Chinese) 2 中华人民共和国国家卫生和计划生育委员会. 国家卫生计生委办公厅关于印发寨卡病毒病诊疗方案的通知[EB/OL].(2016-02-03)[2016-03-15].http://www.nhfpc.gov.cn/yzygj/s3593g/201602/e7c1402a03024501ad3 8f036de346c145.shtml [2] Sikka V, Chattu VK, Popli RK, et al. The emergence of zika virus as a global health security threat: A review and a consensus statement of the INDUSEM Joint working Group (JWG)[J]. J Global Infect Dis, 2016, 8(1): 3-15. doi:10.4103/0974-777X.176140 [3] World Health Organization. Zika virus disease[EB/OL].(2016-03-09)[2016-03-15].http://www.who.int/mediacentre/factsheets/zika/zh/(in Chinese) 世界卫生组织. 寨卡病毒病[EB/OL].(2016-03-09)[2016-03-15].http://www.who.int/mediacentre/factsheets/zika/zh/ [4] Chinese Center for Disease Control and Prevention. Zika virus disease[EB/OL].(2016-03-10)[2016-03-15].http://www.chinacdc.cn/jkzt/crb/ablcxr_8561/(in Chinese) 中国疾病预防控制中心. 寨卡病毒病[EB/OL].(2016-03-10)[2016-03-15].http://www.chinacdc.cn/jkzt/crb/ablcxr_8561/ [5] World Health Organization. Prevention of potential sexual transmission of Zika virus[EB/OL].(2016-02-18)[2016-03-15].http://www.who.int/csr/resources/publications/zika/sexual-transmission-prevention/zh/(in Chinese) 世界卫生组织. 预防寨卡病毒的潜在性传播[EB/OL].(2016-02-18)[2016-03-15].http://www.who.int/csr/resources/publications/zika/sexual-transmission-prevention/zh/ [6] World Health Organization. Zika virus safe blood supply: Questions and answers[EB/OL].(2016-02-19)[2016-03-15].http://www.who.int/features/qa/zika-safe-blood/zh/(in Chinese) 世界卫生组织. 寨卡病毒与安全血液供应专题问答[EB/OL].(2016-02-19)[2016-03-15].http://www.who.int/features/qa/zika-safe-blood/zh/ [7] European Centre for Disease Prevention and Control. Rapid Risk Assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain Barr syndrome. Third update, 23 February 2016[EB/OL].(2016-02-26)[2016-03-15].http://ecdc.europa.eu/en/publications/Publications/zika-virus-rapid-risk-assessment-23-february-2016.pdf [8] World Health Organization. Zika virus disease interim case definition[EB/OL].(2016-02-12)[2016-03-15].http://www.who.int/csr/disease/zika/case-definition/zh/(in Chinese) 世界卫生组织. 寨卡病毒病暂行病例定义[EB/OL].(2016-02-12)[2016-03-15].http://www.who.int/csr/disease/zika/case-definition/zh/ [9] Gubler DJ, Kuno G, Markoff L. Flaviviruses. Fields virology[M]. 5 th edn. Philadelphia: Lippincott Williams and Wilkins Publishers, 2007. [10] Knipe DM, Howley PM. Fields virology[M]. 5 th edn. Philadelphia: Lippincott Williams and Wilkins Publishers, 2007: 1156, 1199. [11] Swiss Institute of Bioinformatics. Zika virus (strain Mr 766)[EB/OL].(2016-03-10)[2015-03-15].http://viralzone.expasy.org/all_by_species/6756.html [12] Chambers T, Hahn C, Galler R, et al. Flavivirus genome organization, expression, and replication[J]. Annu Rev Microbiol, 1990, 44: 649-688. [13] Kuno G, Chang GJ. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses[J]. Arch Virol, 2007, 152: 687-696. [14] Faye O, Freire CCM, Iamarino A, et al. Molecular evolution of Zika virus during its emergence in the 20th century[J]. PLoS Negl Trop Dis, 2014, 8(1): e2636. doi:10.1371/journal.pntd.0002636 [15] Clarke BD, Roby JA, Slonchak A, et al. Functional non-coding RNAs derived from the flavivirus 3' untranslated region[J]. Virus Res, 2015, 206: 53-61. doi:10.1016/j.virusres.2015.01.026 [16] Manokaran G, Finol E, Wang C, et al. Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness[J]. Science, 2015, 350(6257): 217-221. doi:10.1126/science.aab3369 [17] Swiss Institute of Bioinformatics. Flaviviridae[EB/OL].(2016-03-09)[2016-03-15].http://viralzone.expasy.org/all_by_species/43.html [18] Kuno G, Chang GJJ. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses[J]. Arch Virol, 2007, 152(4): 687-696. doi:10.1007/s00705-006-0903-z [19] Enfissi A, Codrington J, Roosblad J, et al. Zika virus genome from the Americas[J]. Lancet, 2016, 387(10015): 227-228. doi:10.1016/S0140-6736(16)00003-9 [20] Zanluca C, de Melo VC, Mosimann AL, et al. First report of autochthonous transmission of Zika virus in Brazil[J]. Memorias do Instituto Oswaldo Cruz, 2015, 110(4): 569-572. doi:10.1590/0074-02760150192 [21] Hayes EB. Zika virus outside Africa[J]. Emerg Infect Dis, 2009, 15(9): 1347-1350. doi:10.3201/eid1509.090442 [22] Chastain M. National Institutes of Health: Zika vrus is a 'pandemic'[J]. Breitbart, 2016. [23] Gatherer D, Kohl A. Zika virus: a previously slow pandemic spreads rapidly through the Americas[J]. J Gen Virol, 2015, 97(2): 269-273. doi:10.1099/jgv.0.000381 [24] Centers for Disease Control and Prevention. Zika virus disease in the United States, 2015-2016[EB/OL].(2016-02-20)[2016-03-15].http://www.cdc.gov/zika/geo/united-states.html [25] Dick GW, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity[J]. Trans R Soc Trop Med Hyg, 1952, 46: 509-520. [26] Science. Zika's long, strange trip into the limelight[EB/OL].(2016-02-10)[2016-03-15].http://www.sciencemag.org/news/2016/02/zika-s-long-strange-trip-limelight [27] Haddow AD, Schuh AJ, Yasuda CY, et al. Genetic characterization of Zika virus strains: Geographic expansion of the Asian lineage[J]. PLoS Negl Trop Dis, 2012, 6(2): e1477. doi:10.1371/journal.pntd.0001477 [28] International Society for Infectious Diseases. ZIKA VIRUS (06): OVERVIEW 2016-02-09 19:58:3 Archive Number: 20160209.4007411[EB/OL].(2016-02-09)[2016-03-15].http://promedmail.org/post/4007411 [29] Duffy MR, Chen TH, Hancock WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia[J]. N Engl J Med, 2009, 360: 2536-2543. [30] Cao-Lormeau VM, Roche C, Teissier A, et al. Zika virus, French polynesia, South pacific, 2013[J]. Emerg Infect Dis, 2014, 20: 1085-1086. [31] Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area[J]. Clin Microbiol Infect, 2014, 20: O595-596. [32] Musso D, Cao-Lormeau VM, Gubler DJ3. Zika virus: following the path of dengue and chikungunya?[J]. Lancet, 2015, 386: 243-244. [33] European Centre for Disease Prevention and Control. Rapid Risk Assessment: Zika virus infection outbreak, Brazil and the Pacific region[EB/OL].(2015-05-25)[2016-03-15].http://ecdc.europa.eu/en/publications/Publications/rapid-risk-assessment-Zika%20virus-south-america-Brazil-2015.pdf [34] Solomon Islands Broadcasting Corporation. Health authorities declare outbreak of new virus in Solomons[EB/OL].[2015-03-15].http://www.sibconline.com.sb/health-authorities-declare-outbreak-of-new-virus-in-solomons/ [35] Pacific Community. Epidemic and emerging disease alerts in the Pacific region as of 29 February 2016[EB/OL].(2016-02-29)[2016-03-15].http://reliefweb.int/map/world/epidemic-and-emerging-disease-alerts-pacific-region-29-february-2016 [36] Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil[J]. Emerg Infect Dis, 2015, 21: 1885-1886. [37] Zanluca C, de Melo VC, Mosimann AL, et al. First report of autochthonous transmission of Zika virus in Brazil[J]. Mem Inst Oswaldo Cruz, 2015, 110: 569-572. [38] Musso D. Zika virus transmission from French Polynesia to Brazil[J]. Emerg Infect Dis, 2015, 21: 1887. [39] Wæhre T, Maagard A, Tappe D, et al. Zika virus infection Diertravel to Tahiti, December 2013[J]. Emerg Infect Dis, 2014, 20: 1412-1414. [40] Zammarchi L, Stella G, Mantella A, et al. Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications[J]. J Clin Virol, 2015, 63: 32-35. [41] Brust KB, Prince WS, Fader RC. Trouble in paradise[J]. IDCases, 2014, 1: 95-96. [42] Kutsuna S, Kato Y, Takasaki T, et al. Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014[J]. Euro Surveill, 2014, 19(4)pii=20683. doi:10.2807/1560-7917.ES2014.19.4.20683 [43] Centers for Disease Control and Prevention. CDC encourages following guidance to prevent sexual transmission of Zika virus[EB/OL].(2015-02-23)[2015-03-15].http://www.cdc.gov/media/releases/2016/s0223-zika-guidance.html [44] Schuler-Faccini L, Ribeiro EM, Feitosa IM, et al. Possible association between Zika virus infection and microcephaly-Brazil, 2015[J]. Morb Mortal Wkly Rep, 2016, 65(3): 59-62. doi:10.15585/mmwr.mm6503e2 [45] Musso D, Roche C, Robin E, et al. Potential sexual transmission of Zika virus[J]. Emerg Infect Dis, 2015, 21: 359-361. [46] Musso D, Nhan T, Robin E, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014[J]. Euro Surveill, 2014, 19(14): pii=20761. doi:10.2807/1560-7917.ES2014.19.14.20761 [47] Fauci AS, Morens DM. Zika Virus in the Americas-Yet Another Arbovirus Threat[J]. N Engl J Med, 2016, 374(2): 160113142101009. doi:10.1056/NEJMp1600297 [48] Darwish MA, Hoogstraal H, Roberts TJ, et al. A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan[J]. Trans R Soc Trop Med Hyg, 1983, 77(4): 442-445. [49] Ayres CFJ. Identification of Zika virus vectors and implications for control[J]. Lancet Infect Dis, 2016, 16(3): 278-279. doi:10.1016/S1473-3099(16)00073-6 [50] Grard G, Caron M, Mombo IM, et al. Zika virus in Gabon (Central Africa)-2007: A new threat from Aedes albopictus ?[J]. PLOS Negl Trop Dis, 2014, 8(2): e2681. doi:10.1371/journal.pntd.0002681 [51] Zammarchi L, Stella G, Mantella A, et al. Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications[J]. J Clin Virol, 2015, 63: 32-35. doi:10.1016/j.jcv.2014.12.005 [52] Kraemer MUG, Sinka ME, Duda KA, et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. Albopictus [J]. ELife, 2015, 4: e08347. doi:10.7554/eLife.08347 [53] Science. Sex after a field trip yields scientific first[EB/OL].(2011-04-06)[2016-03-15].http://www.sciencemag.org/news/2011/04/sex-after-field-trip-yields-scientific-first?ref=hp [54] Oster AM, Brooks JT, Stryker JE, et al. Interim guidelines for prevention of sexual transmission of Zika virus - United States, 2016[J]. Morb Mortal Wkly Rep, 2016, 65(5): 120-121. [55] Foy BD, Kobylinski KC, Foy JLC, et al. Probable non vector-borne transmission of Zika virus, Colorado, USA[J]. Emerg Infect Dis, 2011, 17(5): 880 882. doi:10.3201/eid1705.101939 [56] Dallas County Health and Human Services. DCHHS reports first Zika virus case in Dallas County acquired through sexual transmission[EB/OL].(2016-02-06)[2016-03-15].http://www.dallascounty.org/department/hhs/press/documents/PR2-2-16DCHHSReportsFirstCaseofZikaVirusThroughSexual Transmission.pdf?dom=pscau&src=syn [57] Centers for Disease Control and Prevention. CDC encourages following guidance to prevent sexual transmission of Zika virus[EB/OL].(2016-02-23)[2016-03-15].http://www.cdc.gov/media/releases/2016/s0223-zika-guidance.html [58] Venturi G, Zammarchi L, Fortuna C, et al. An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014[J]. Eurosurveillance, 2016, 21(8): pii=30148. doi:10.2807/1560-7917.ES.2016.21.8.30148 [59] Martines RB, Bhatnagar J, Keating MK, et al. Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses - Brazil, 2015[J]. Morb Mortal Wkly Rep, 2016, 65(6): 159 160. doi:10.15585/mmwr.mm6506e1er [60] Mallet HP, Vial AL, Musso D. Bilan de l'épidémie à virus Zika en Polynésie fran.aise, 2013-2014[J]. Bulletin d'information sanitaire, épidémiologique et statistique, 2015,13:1-5. [61] World Health Organization. WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barr syndrome[EB/OL].(2016-02-01)[2016-03-15].http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/zh/(in Chinese) 世界卫生组织. 世卫组织总干事总结寨卡病毒突发事件委员会的会议结果[EB/OL].(2016-02-01)[2016-03-15].http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/zh/ [62] Oliveira Melo AS, Malinger G, Ximenes R, et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?[J]. Ultrasound Obstet Gynecol, 2016, 47 (1): 6-7. doi:10.1002/uog.15831 [63] Mlakar J, Korva M, Tul N, et al. Zika virus associated with microcephaly[J]. N Engl J Med, 2016, 374: 951-958. doi:10.1056/NEJMoa1600651 [64] World Health Organization. Zika situation report[EB/OL].(2016-02-05)[2016-03-15].http://apps.who.int/iris/bitstream/10665/204348/1/zikasitrep_5Feb2016_eng.pdf?ua=1 [65] Brasil P, Pereira JP, Gabaglia CE Jr, et al. Zika virus infection in pregnant women in Rio de Janeiro - preliminary report[J]. N Engl J Med, 2016. doi:10.1056/NEJMoa1602412 [66] Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy - Brazil, 2015[J]. Morb Mortal Wkly Rep, 2016, 65: 242 247. doi:10.15585/mmwr.mm6509e2 [67] Sarno M, Sacramento GA, Khouri R, et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise[J]. PLoS Negl Trop Dis, 2016, 10(2): e0004517. doi:10.1371/journal.pntd.0004517 [68] Meaney-Delman D, Hills SL, Williams C, et al. Zika virus infection among U.S. pregnant travelers - August 2015 February 2016[J]. MMWR Morb Mortal Wkly Rep, 2016, 65: 211 214. doi:10.15585/mmwr.mm6508e1 [69] Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth[J]. Cell Stem Cell, 2016, 18: 1-4. doi:10.1016/j.stem.2016.02.016 [70] Fauci AS, Morens DM. Zika virus in the Americas-Yet another arbovirus threat[J]. N Engl J Med, 2016, 374(2): 160113142101009. doi:10.1056/NEJMp1600297 [71] Oehler E, Watrin L, Larre P, et al. Zika virus infection complicated by Guillain-Barre syndrome case report, French Polynesia, December 2013[J]. Euro Surveill, 2014, 19(9): 20720. [72] Ioos S, Mallet HP, Leparc GI, et al. Current Zika virus epidemiology and recent epidemics[J]. Med Mal Infect, 2014, 44: 302-307. [73] Cao-Lormeau V, Blake A, Mons S, et al. Guillain-Barr Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study[J]. Lancet, 2016. doi:10.1016/S0140-6736(16)00562-6 [74] Lanciotti RS, Kosoy OL, Laven JJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007[J]. Emerg Infect Dis, 2008, 14: 1232-1239. [75] Kuno G. Serodiagnosis of flaviviral infections and vaccinations in humans[J]. Adv Virus Res, 2003, 61: 3-65. [76] Musso D, Roche C, Nhan TX, et al. Detection of Zika virus in saliva[J]. J Clin Virol, 2015, 68: 53-55. [77] Gourinat AC, O'Connor O, Calvez E, et al. Detection of Zika virus in urine[J]. Emerg Infect Dis, 2015, 21: 84-86. [78] Centers for Disease Control and Prevention. New CDC laboratory test for Zika virus authorized for emergency use by FDA[EB/OL].(2016-02-16)[2016-03-15].http://www.cdc.gov/media/releases/2016/s0226-laboratory-test-for-zika-virus.html [79] Centers for Disease Control and Prevention. Symptoms, Diagnosis, & Treatment[EB/OL].(2016-03-04)[2016-03-15].https://en.m.wikipedia.org/wiki/Centers_for_Disease_Control_and_Prevention [80] Chan JFW, Choi GKY, Yip CCY, et al. Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease?[J]. J Infect, 2016, in press. doi:10.1016/j.jinf.2016.02.011 [81] Bennett JE, Dolin R, Blaser MJ. Principles and practice of infectious diseases[M]. New York: Elsevier Health Sciences, 2014: 1881. [82] Scientific American. First dengue fever vaccine gets green light in 3 countries[EB/OL].(2016-01-28)[2016-03-15].http://www.scientificamerican.com/article/first-dengue-fever-vaccine-gets-green-light-in-3-countries [83] World Health Organization. WHO and experts prioritize vaccines, diagnostics and innovative vector control tools for Zika R&D[EB/OL].(2016-03-13)[2016-03-15].http://www.who.int/mediacentre/news/notes/2016/research-development-zika/en/ [84] US News & World Report. Vaccine efforts underway as Zika virus spreads[EB/OL].(2016-01-28)[2016-03-15].http://www.usnews.com/news/articles/2016-01-22/vaccine-efforts-underway-as-zika-virus-spreads [85] World Health Organization. WHO and experts prioritize vaccines, diagnostics and innovative vector control tools for Zika R&D[EB/OL].(2016-03-09)[2016-03-15].http://www.who.int/mediacentre/news/notes/2016/research-development-zika/en/ [86] Musso D, Nhan TX. Emergence of Zika virus[J]. Clin Microbiol, 2015, 4: 5. doi:10.4172/2327-5073.1000222 [87] Oster AM, Brooks JT, Stryker JE, et al. Interim guidelines for prevention of sexual transmission of Zika virus - United States, 2016[J]. Morb Mortal Wkly Rep, 2016, 65: 1 2. [88] BBC. Zika virus triggers pregnancy delay calls[EB/OL]. http://www.bbc.com/news/world-latin-america-35388842, 2016-01-23/2016-03-15. [89] World Health Organization. Mosquito control: can it stop Zika at source?[EB/OL].(2016-02-19)[2016-03-15].http://www.who.int/emergencies/zika-virus/articles/mosquito-control/zh/(in Chinese) 世界卫生组织. 控制蚊子能否从源头阻断寨卡?[EB/OL].(2016-02-19)[2016-03-15].http://www.who.int/emergencies/zika-virus/articles/mosquito-control/zh/ [90] Centers for Disease Control and Prevention. CDC issues advice for travel to the 2016 Summer Olympic Games[EB/OL].(2016-02-26)[2016-03-15].http://www.cdc.gov/media/releases/2016/s0226-summer-olympic-games.html
2016, Vol. 32 
