Biological characteristics and research progress about Burkholderia pseudomallei intracellular movement associated protein (BimA)
HU Yi, FANG Yao, MAO Xu-hu
Department of Clinical Microbiology and Immunology,College of Medical Laboratory Science, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China
Abstract:Burkholderia pseudomallei, a tropical medicine pathogen, is listed as Titer I' pathogen by US Centers for Disease Control and Prevention. It is widely spread in Southeast Asia and the surrounding area of the South Sea of China. Its associated disease is melioidosis, with a high mortality and relapse rate, which has become a serious problem for public health. As an intracellular bacteria, its ability for intercellular motility plays a key role in its immunity escape and cell-to-cell diffusion. Burkholderia pseudomallei intracellular movement associated protein (BimA), an auto-secreted protein of B. Pseudomallei, takes part in manipulating intracellular actin function and associates with the pathogenicity of B. Pseudomallei. Comprehensive and in-depth understanding about BimA and associated mechanism would benefit prevention and control of the pathogen. This review focuses on the biological characteristics and research progress about BimA to discuss its roles in B. Pseudomallei intracellular movement, immunity escape and cell-to-cell diffusion.
胡艺, 方瑶, 毛旭虎. 类鼻疽伯克霍尔德菌胞内运动相关蛋白BimA的生物学特性研究进展[J]. 中国人兽共患病学报, 2016, 32(3): 286-289.
HU Yi, FANG Yao, MAO Xu-hu. Biological characteristics and research progress about Burkholderia pseudomallei intracellular movement associated protein (BimA). Chinese Journal of Zoonoses, 2016, 32(3): 286-289.
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