Advance in Herpesvirus US10 gene and its encoded protein
ZHANG Dai-xi, CHENG An-chun, WANG Ming-shu
Avian Diseases Research Center, College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Diseases and Human Health of Sichuan Province/Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Abstract：US10 gene of Herpesvirus is located in the short unique region of its genome and not essential for virus replication. US10 gene encodes a phosphorylated tegument-capsid associated protein or type I transmembrane glycoprotein which selectively targets the cytoplasmic tail of HLA-G,a kind of nonclassical class I MHC molecular, to reduce and block the host NK cell cytotoxicity in immune evasion. US10 can also interact with host proteins to play a pathogenic role and regulate the expression of other viral proteins such as glycoprotein E (gE). Through further research, the role of US10 in virulence and its ability to combine with RNA and regulate transcription can be judged in the future.
张代熙, 程安春, 汪铭书. 疱疹病毒US10基因及其编码蛋白研究进展[J]. 中国人兽共患病学报, 2017, 33(1): 61-66.
ZHANG Dai-xi, CHENG An-chun, WANG Ming-shu. Advance in Herpesvirus US10 gene and its encoded protein. Chinese Journal of Zoonoses, 2017, 33(1): 61-66.
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2017, Vol. 33 
